Chad Hancock

Research Interests

My research focus is on metabolic pathways impacted by changes in energy supply and demands. Factors that contribute to insulin resistance and type 2 diabetes are most often a result of a mismatch between metabolic fuel supply (the food energy that we eat) and metabolic fuel demands (the food and stored energy that we burn through activity). We study energy metabolism and factors contributing to the development of insulin resistance using nutritional, exercise and pharmaceutical approaches.
Our general research objectives include the following:
• Understand mechanisms by which lifestyle and other factors contribute to the development of insulin resistance.
• Investigate the effects of different bioactive compounds on glucose management and energy metabolism.
• Explore mechanisms by which various bioactive compounds impact glucose management and energy metabolism.
This research is vitally important to gain a better understanding of the metabolic problems that underpin many chronic diseases impacted by insulin resistance. We expect our work can lead to improved prevention and therapy for diabetes and related disease conditions.
Recent projects of interest include:
• A study looking at the effect of dietary selenium and/or increased isoflavones on insulin resistance and baseline glucose management.
• A study examining the effect of caloric restriction on mitochondrial content.
• A study examining the effect of iron deficiency and specific enzymatic responses to this energy challenge.
• A study examining the effect of high fat diets as well as the activation of a critical enzyme involved in energy sensing (AMPK) on muscle mitochondrial content and capacity.
• A study looking at the effect of high fat diets and activating AMPK on liver fat accumulation.
Current projects of interest include:
• Examining a potential role of cellular iron dysregulation and insulin resistance.
• Exploring the effects of specific bioactive compounds on muscle and hepatic iron metabolism.
• We are examining the possibility that some anti-diabetic therapies may be effective at reducing unwanted toxicities associated with certain chemotherapeutic treatments.
• Exploring the impact of different dietary bioactive compounds on mitochondrial function and the generation of reactive oxygen species.

Honors and Awards

• APS Publications 2015 Star Reviewer, American Physiological Society (2015 - 2016)

Memberships

• American College of Sports Medicine
• American Diabetes Association (2008 - Present)
• The American Physiological Society (2008 - Present)

Professional Citizenship

• Editorial Review Board Member, American Journal of Physiology-Endocrinology and Metabolism (2008 - Present)
• Other, International Journal of Molecular Sciences (2019 - 2021)
• Grant Proposal Reviewer, External, NIH (2015 - 2015)

Courses Taught

Show Previous Years

Publications

Robert D Hyldahl Jayson R Gifford Lance E Davidson Chad R Hancock Paul S Hafen Allen C Parcell Gary W Mack Maci J Jacobsen Alexis M Gardner Camilla Handley Michael W Smith William F Christensen Chad R Hancock Paule V Joseph Michael J Larson Corby K Martin James Derek LeCheminant Erik D Marchant Robert Douglas Hyldahl Jayson R Gifford William Bradley Nelson Chad R Hancock Erik D Marchant Jaimie P Kaluhiokalani Taysom E Wallace Mohadeseh Ahmadi Abigail Dorff Jessica J Linde Olivia K Leach Robert D Hyldahl Jayson R Gifford Chad R Hancock Jason M Hansen S Marc Lucas Catania D Ramos Eli J Green Dakota J Nuttall David S Clark Erik D Marchant Chad R Hancock Ted B Piorczynski Erik Marchant Nathan Marchant Robert Hyldahl Jayson R Gifford Michael Smith Chad Hancock Amy D Mackay Erik D Marchant Makensie Louw David M Thomson Chad R Hancock Erik D. Marchant Nathan D. Marchant Weston S. Elison Jacob A. Herring Haokun Yang Jeffery S Tessem Chad R Hancock Nathan D. Marchant Erik D. Marchant Weston S. Elison Jacob A. Herring Haokun Yang Jeffery S Tessem Chad R Hancock M R Deyhle M Carlisle J R Sorensen P S Hafen K Jesperson M Ahmadi Chad R Hancock Robert Douglas Hyldahl J Koh Chad R Hancock D H Han J O Holloszy K S Nair S Dasari A D Mackay E D Marchant D J Munk Richard Kent Watt Jason Merrell Hansen David Morley Thomson Chad R Hancock K. B. Kener D. J. Munk Chad R Hancock Jeffery S Tessem D. J. Tueller J. S. Harley Chad R Hancock J. H. Koh Chad R Hancock S. Terada K. Higashida J. O. Holloszy D. H. Han M S Reynolds Chad R Hancock J D Ray K B Kener C Draney K Garland J Hardman Benjamin Thomas Bikman Jeffery S Tessem Ting Chen Timothy M Moore Mark T Ebbert Natalie L McVey Steven R Madsen David M Hallowell Alex M Harris Ryan P Mackay Robin E Char Chad R Hancock Jason Merrell Hansen John Sai Keong Kauwe David Morley Thomson Shalene E Hardman Derrick E Hall Alyssa J Cabrera Chad R Hancock David Morley Thomson Michael T. Stallings Brandon R. Cardon Jeremy M. Hardman Tyler A. Bliss Scott E. Brunson Chris M. Hart Maria D. Swiss Squire D. Hepworth Merrill J Christensen Chad R Hancock Laura Clarke Bridgewater Jaime L Mayo Bradley G Evanson Megan E Whitt Spencer A Dean Joshua D Yates Devin N Holden Alina D Schmidt Christopher L Fox Saroj Dhunghel Kevin S Steed Michael M Adam Caitlin A Nichols Sampath K Loganathan Jeffery Richard Barrow Chad R Hancock Bradley S Henriksen Mary E Curtis Natasha Fillmore Brandon R Cardon David Morley Thomson Chad R Hancock J. F. Merrill David Morley Thomson S. E. Hardman S. D. Hepworth S. Willie Chad R Hancock Katerhine A Erickson Melissa E Smith Tamil S Anthonymuthu Eric S Brassfield Braden J Tucker John T Prince Chad R Hancock Benjamin Thomas Bikman Dong-Ho Han Chad R Hancock Su Ryun Jung Kazuhiko Higashida Sang Hyun Kim John O Holloszy J D Brown Chad R Hancock A D Mongillo B J Barton R A Digiovanni Allen Clive Parcell William W Winder David Morley Thomson Chad R Hancock D H Han K Higashida S H Kim John O Holloszy David Morley Thomson Chad R Hancock B G Evanson S G Kenney B B Mallan A D Mongillo J D Brown S Hepworth N Fillmore Allen Clive Parcell David Lee Kooyman William W Winder

Presentations