Jeff Tessem

Research Interests

Both Type 1 and Type 2 diabetes are caused by a relative insufficiency in functional β-cell mass. Current therapeutic options for diabetes include daily insulin injections to maintain normoglycemia, pharmacological agents to stimulate β-cell function and enhance insulin sensitivity, or islet transplantation. A major obstacle to greater application of islet transplantation therapy is the scarcity of human islets. Thus, new methods for expansion of β-cell mass, applied in vitro to generate the large numbers of human islet cells needed for transplantation, or in situ to induce expansion of the patients remaining β-cells, could have broad therapeutic implications for this disease. To this end, our lab is interested in delineating the molecular pathways that increase β-cell proliferation, enhance glucose stimulated insulin secretion, and protect against β-cell death.

Teaching Interests

My teaching interests focus on nutrient metabolism, biochemistry and cellular function. I am interested in the metabolic disorders that cause human diseases.

Education

• Postdoctoral Fellowship, Beta Cell Biology , Duke University (2013)
• Ph.D., Biochemistry and Molecular Biology , Biophysics and Genetics, University of Colorado Health Sciences Center (2007)
• BS, Microbiology , Chemistry and Portugues, Brigham Young University (2001)

Honors and Awards

• Skaggs Distinguished Mentoring Fellowship, BYU Life Science College (2020 - 2023)
• 2018 Meg Award, BYU ORCA (2018 - 2019)
• Innovative Basic Science Award, American Diabetes Association (2017 - 2019)
• Research Award, Diabetes Action Research and Education Foundation (2017 - 2018)
• 2016 MEG Recipient, BYU ORCA (2016 - 2018)
• JDRF Utah Chapter Hope for the Future Award, Utah Chapter of the Juvenile Diabetes Research Foundation (2016 - 2017)
• Beta Cell Biology Consortium Investigator Scholarship, Beta Cell Biology Consortium (2011 - 2011)
• Keystone Symposium/NIDDK Scholarship, Keystone Symposium (2010 - 2010)

Memberships

• American Association for the Advancement of Science (2017 - Present)
• American Society for Biochemistry and Molecular Biology (2017 - Present)
• American Heart Association (2014 - Present)
• American Physiological Society (2014 - Present)
• American Society for Nutrition (2014 - Present)
• Danish Diabetes Academy (2014 - Present)
• American Diabetes Association (2011 - Present)

Professional Citizenship

• Editorial Review Board Member, Frontiers in Endocrinology, Diabetes: Study of Pancreatic Islets Based on Human Models to Understand Pathogenesis of Diabetes (2021 - Present)
• Editorial Review Board Member, Nutrition Research (2021 - Present)
• Committee/Council Member, American Diabetes Association National Islet Biology, Development, and Function interest group (2021 - Present)
• Editorial Review Board Member, Biology Journal (2020 - Present)
• Editorial Review Board Member, Pharmaceutical Journal (2020 - Present)
• Committee/Council Member, American Physiology Society-Endocrinology and Metabolism Section (2020 - Present)
• Editorial Review Board Member, Frontiers in Endocrinology, Diabetes: Molecular Mechanisms (2019 - Present)
• Reviewer, Ad Hoc Reviewer, Diabetes Journal (2016 - Present)
• Reviewer, Ad Hoc Reviewer, Journal of Molecular Cell Biology (2016 - Present)
• Reviewer, Ad Hoc Reviewer, PLOS ONE Journal (2016 - Present)
• Reviewer, Ad Hoc Reviewer, American Journal of Physiology - Endocrinology and Metabolism (2016 - Present)
• Committee/Council Member, JDRF (2015 - Present)
• Reviewer, Ad Hoc Reviewer, JDRF (2013 - Present)
• Committee/Council Member, American Physiology Society-Communication Committee (2017 - 2020)
• Reviewer, Ad Hoc Reviewer, NIN-NIDDK-Molecular and Cellular Endocrinology Review Panel (2016 - 2019)

Courses Taught

Show Previous Years

Publications

Jeffery S Tessem Kathryne Racine Lisard Iglesias-Carres Jacob Herring Mario Ferruzzi Colin Kay Andrew Nelson Jeffery S Tessem Jack Allen Jeffery S Tessem Lisard Iglesias-Carres Emily Krueger Jacob Herring Andrew Nelson Talon J. Aitken Jacqueline E. Crabtree Daelin M. Jensen Kavan H. Hess Brennan R. Leininger Jeffery S. Tessem Laura E. Griffin Lauren Essenmacher Kathryn C. Racine Lisard Iglesias-Carres Jeffery S Tessem Susan M. Smith Andrew P. Neilson Shane P. Simonett Sunyoung Shin Jacob A. Herring Rhonda Bacher Linsin A. Smith Chenyang Dong Mary E. Rabaglia Donnie S. Stapleton Kathryn L. Schueler Jeea Choi Matthew N. Bernstein Daniel R. Turkewitz Carlos Perez-Cervantes Jason Spaeth Roland Stein Jeffery S. Tessem Christina Kendziorski Sunduz Keles Ivan P. Moskowitz Mark P. Keller Alan D. Attie Emily S. Krueger Trevor S. Lloyd Jeffery S. Tessem E S Krueger J L Beales K B Russon W S Elison J R Davis Jason Merrell Hansen A P Neilson Jason Merrell Hansen Jeffery S Tessem Kathryn Racine Lisard Iglesias-Carres Lauren Essenmacher Gabriella Agnello Jeffery Tessem Mario Ferruzzi Colin Kay Andrew Neilson Daelin M. Jensen Kyle V. Hendricks Austin T. Mason Jeffery S Tessem T Chen Jonathon T Hill T M Moore Cheung ECK Z E Olsen T B Piorczynski T D Marriott Jeffery S Tessem Chase M Walton Benjamin Thomas Bikman Jason Merrell Hansen David Morley Thomson Jeffery S Tessem Jacob A Herring Weston C Elison Jeffery S Tessem Benjamin F. Bitner Jason D. Ray Kyle B. Kener Jacob A Herring Josie A Tueller Deborah K Johnson Claudia M Tellez Freitas Dane W Fauscnact Mitchel E Allen Alexander H Thomson K Scott Weber Ryan P McMillan Matthew W Hulliver David A Brown Andrew P Neilson Benjamin F. Bitner Jason D. Ray Kyle B. Kener Jacob A. Herring Josie A. Tueller Deborah K. Johnson Freitas, Claudia M. Tellez Dane W. Fausnacht Mitchell E. Allen Alexander H. Thomson Kelly Scott Weber Ryan P. McMillan Matthew W. Hulver David A. Brown Jeffery S. Tessem Andrew P. Neilson C Draney M C Austin A H Leifer C J Smith K B Kener T J Aitken K H Hess Albert Edwyn Haines L A Lett A Hernandez-Carretero P T Fueger M Arlotto Jeffery S Tessem B A Parker C M Walton S T Carr Jason Alan Andrus Cheung ECK M J Duplisea E K Wilson C Draney D R Lathen K B Kenner David Morley Thomson Jeffery S Tessem Benjamin Thomas Bikman B A Parker C M Walton S T Carr J L Andrus Cheung ECK M J Duplisea E K Wilson C Draney D R Lathen K B Kenner David Morley Thomson Jeffery S Tessem Benjamin Thomas Bikman K. B. Kener D. J. Munk Chad R Hancock Jeffery S Tessem T J Rowley, 4th B F Bitner J D Ray D R Lathen A T Smithson B W Dallon C J Plowman Benjamin Thomas Bikman Jason Merrell Hansen M R Dorenkott K M Goodrich L Ye S F O'Keefe A P Neilson Jeffery S Tessem C J Banks N W Rodriguez K R Gashler R R Pandya J B Mortenson M D Whited E J Soderblom J W Thompson M A Moseley A R Reddi Jeffery S Tessem M P Torres Benjamin Thomas Bikman Joshua Andersen MaryJane Sampson Daniel R Lathen Blake W Dallon Carrie Draney Jason D Ray Kyle B Kener Brian A Parker Jonathan L Gibbs Jarom S Gropp Jeffery S Tessem Benjamin Thomas Bikman M S Reynolds Chad R Hancock J D Ray K B Kener C Draney K Garland J Hardman Benjamin Thomas Bikman Jeffery S Tessem J D Ray K B Kener B F Bitner B J Wright Michael Barclay Ballard E J Barrett Jonathon T Hill L G Moss Jeffery S Tessem Jeffery S Tessem Karen M Strat Thomas J Rowley Andrew T Smithson Matthew W Hulver Dongmin Liu Brenda M Davey Kevin P Davy Andrew P Neilson Jeffery S Tessem CArrie Draney Amanda E Hobson Samuel G Grover Benjamin O Jack Amanda Hobson Carrie Draney Andrew Stratford Tom C Becker Danhong Lu Michelle Arlotto Jeffery S Tessem Jeffery S Tessem L G Moss L C Chao M Arlotto D Lu M V Jensen S B Stephens P Tontonoz H E Hohmeier C B Newgard Jeffery S Tessem Jan N Jensen Hanna Pelli Xu M Dai Xiao H Zong Richard E Stanley Jan Jensen James DeGregori Jeffery S Tessem Jonathon C Schisler Patrick T Fueger Daniella A Babu Hans E Hohmeier Danhong Lu Thomas C Becker Bashoo Naziruddin Marlon Levy Ragvhavendra G Mirmira Christopher B Newgard Jeffery S Tessem J DeGregori F X Li J W Zhu Jeffery S Tessem J Beilke M Varella-Garcia J Jensen C J Hogan J DeGregori